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    • University of Missouri-Columbia
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    • Clinical Inquiries, 2009
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    Can nonantidepressants help treat depression?

    Chilakamarri, Geetha
    Weismantel, David
    Weismantel, Arlene McFarlin
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    [PDF] CanNonantidepressantsHelpTreat.pdf (113.7Kb)
    Date
    2009
    Format
    Article
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    Abstract
    lithium, triiodothyronine (T3), and atypical antipsychotics are all effective adjuncts. Lithium (serum levels >0.5 mEq/L) can produce clinical improvement when added to ineffective antidepressant treatment (strength of recommendation [SOR]: A, meta-analysis of randomized controlled trials [RCTs]). Thyroid supplementation using T3 at doses no higher than 50 mcg per day also increases the effectiveness of antidepressant therapy (SOR: B, meta- analysis of RCT and cohort studies). Atypical antipsychotic agents are less effective adjuncts for patients with treatment-resistant major depressive disorder (SOR: B, meta-analysis of RCT and cohort studies).
    URI
    http://hdl.handle.net/10355/3862
    Part of
    Journal of family practice, 58, no. 10 (October 2009): 550-551.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2009

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