When should you suspect community-acquired MRSA? How should you treat it?

Abstract

There are no clinical or epidemiologic features that will help you to clearly distinguish community-acquired methicillin-resistant Staphylococcus aureus infections (CA-MRSA) from methicillin-sensitive (CA-MSSA) infections (strength of recommendation [SOR]: B, prospective cohort studies). Incision and drainage is the primary therapy for purulent skin and soft tissue infections (SOR: B, randomized, controlled clinical trials [RCTs]). There are inadequate data evaluating the role of oral antibiotics for MRSA (SOR: B, single RCT).