Antidepressant Medications in Pregnancy

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are considered first-line agents for the treatment of depression in pregnant women. SSRIs and tricyclic antidepressants (TCAs) are considered safe and effective in pregnant women, although some studies have indicated increased short-term neonatal adverse effects after exposure to antidepressants in the third trimester.[Strength of recommendation: B, based on cohort studies.]