Raloxifene for Prevention of Osteoporotic Fractures
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Raloxifene (60 mg daily for three years) will prevent one vertebral fracture, including asymptomatic fractures, for every 46 postmenopausal women with osteoporosis or presence of previous vertebral fractures. Raloxifene has not been shown to prevent nonvertebral fractures. It is unclear if longer duration of treatment is warranted, or whether this risk reduction is sustained after discontinuation of treatment. [Strength of recommendation: A, based on systematic reviews of randomized controlled trials (RCTs)]
American Family Physician, 72(1) 2005.