Colorectal Cancer Screening
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Both fecal occult blood testing (FOBT) and flexible sigmoidoscopy are effective in screening for colorectal cancer. FOBT can reduce mortality from colorectal cancer. [Strength of recommendation: A, based on high-quality systematic reviews of randomized controlled trials (RCTs)] Flexible sigmoidoscopy has a higher diagnostic yield, but its effect on colorectal cancer mortality has been less rigorously demonstrated. [Strength of recommendation: B, based on high-quality systematic reviews of well-designed case-control studies]
American Family Physician, 71(5) 2005.