Warfarin for Prevention of Ischemic Stroke Recurrence?
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There is no evidence that anticoagulation with warfarin, initiated after a non- cardioembolic ischemic stroke, significantly reduces stroke recurrence. Furthermore, anticoagulation significantly increases the risk of fatal and nonfatal hemorrhagic stroke and extracranial hemorrhage in these patients. However, warfarin clearly is indicated for patients who have embolic strokes caused by underlying conditions such as atrial fibrillation or myxoma. (Strength of recommendation: A)
Clinical Inquiries, 2006 (MU)
American Family Physician, 73(11) 2006.