• Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants 

    Stegner, Andrew L. (University of Missouri--Columbia, 2005)
    The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly ...
  • Regulation of ceramide synthase 1 in cellular stress response 

    Sridevi, Priya (University of Missouri--Columbia, 2008)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase ...
  • Sphingolipid metabolic enzymes modulate anticancer drug resistance 

    Min, Junxia (University of Missouri--Columbia, 2006)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Resistance to anticancer drugs is still a big obstacle for effective chemotherapy.To understand the underlying mechanisms, we generated sphingosine-1-phosphate ...