Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Advisor "Cook, James L. (James Lee), 1965-"
Now showing items 1-9 of 9
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Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ... -
Comprehensive characterization of canine meniscal pathology
(University of Missouri--Columbia, 2010)Meniscal injury is one of the most common causes of pain and dysfunction in the human knee and canine stifle joint. In the canine patient, meniscal injury is usually secondary to cranial cruciate ligament rupture, and the ... -
Cruciate ligament pathogenesis and its role in the initiation and progression of osteoarthritis
(University of Missouri--Columbia, 2008)The pathogenesis of cruciate ligament disease and how it may be linked to the initiation and progression of osteoarthritis were investigated using in vitro and in vivo models. Normal and diseased tissues were initially ... -
Development and characterization of a novel meniscal extracellular matrix-derived scaffold /
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Despite advances in orthopaedic surgery, effective treatments ... -
Development of a post-traumatic osteoarthritis model to evaluate the effects of impact velocity and maximum strain on articular cartilage cell viability, matrix biomarkers, and material properties
(University of Missouri--Columbia, 2009)Post-traumatic osteoarthritis (PTOA) is a very painful and debilitating disease that is associated with mechanical injury to articular cartilage, yet the severity of trauma required to induce it is unknown. The objective ... -
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ... -
Development of post-traumatic osteoarthritis models to evaluate the effects of impact injury on joint health for clinical disease treatment and prevention
(University of Missouri--Columbia, 2013)Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic ... -
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ... -
The role of load in initiation and progression of cartilage pathology
(University of Missouri--Columbia, 2007)Articular cartilage is primarily responsible for dissipation of load in diarthrodial joints. Load plays a critical role in maintaining cartilage health, but can also be a primary contributing factor in cartilage disease ...