Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Advisor "Ding, Shinghua"
Now showing items 1-8 of 8
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Deletion of IP₃ receptor2 in astrocytes enhances the hippocampal neurogenesis in adult mice
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Neurogenesis (birth of neurons) is a process by which neurons are generated from neural progenitor cells. It mainly occurs in two regions of brain, one ... -
The impact of neuronal Nampt on motor function of mice
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Nicotinamide phosphoribosyltransferase (Nampt), also named visfatin and pre-B cell colony-enhancing factor (PBEF), is the rate-limiting enzyme converting ... -
Impact of the NAD+ salvage pathway on the motor system and bioenergetics
(University of Missouri--Columbia, 2023)Nicotinamide adenine dinucleotide (NAD+) is a metabolite pivotal to numerous cellular functions, including energy metabolism, DNA repair, and protein modification. The majority of NAD+ is generated by the NAD+ salvage ... -
Metabolic alterations in reactive astrocytes and their roles in ischemic stroke
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 12/1/2024] Focal ischemic stroke (FIS) is a severe neurological disease that lacks effective remedy. Astrocytes are the predominant glial cell types in the central nervous system (CNS) and exert critical ... -
Regulation of calcium signaling by p130PH in astrocytes
(University of Missouri--Columbia, 2009)Ca2+ signaling is a characteristic form of astrocyte excitability, but its role in ischemia is not clearly understood. Our previous study (Ding et al., 2009) demonstrated that astrocytes exhibit enhanced Ca2+ signaling ... -
The role of astrocytic calcium signaling in brain damage after photothrombosis
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ischemic stroke is the third leading cause of death in industrialized countries. Our previous study found elevated [Ca[superscript 2+]]i signals in ... -
The role of metabotropic glutamate receptor 5 in cerebral ischemia
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Group I metabotropic glutamate receptor 5 (mGluR5), belongs to G-protein coupled receptors family and plays important roles in CNS disorders including ... -
The role of Pre-B-cell colony-enhancing factor in neuronal death after ischemia and motor dysfunction
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pre-B-cell colony-enhancing factor (PBEF) is the rate-limiting enzyme in the salvage pathway of mammalian nicotinamide adenine dinucleotide (NAD+) ...