Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Advisor "Hwang, Tzyh-Chang"
Now showing items 1-10 of 10
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CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs ... -
CFTR gating mechanism : the role of dimerization of nucleotide binding domains
(University of Missouri--Columbia, 2009)The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ... -
Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ... -
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ... -
Molecular mechanisms of action for CFTR potentiators
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ... -
Molecular physiology and pharmacology of the CFTR chloride channel
(University of Missouri--Columbia, 2012)Cystic fibrosis transmembrane conductance regulator (CFTR) is the only ATP binding cassette (ABC) protein that functions as an ion channel. The clinical importance of CFTR lies in the fact that its malfunction causes the ... -
New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cystic Fibrosis (CF), caused by the loss of function in the gene for the protein cystic fibrosis transmembrane conductance (CFTR), is one of the most ... -
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ... -
Structural/functional insights derived from studies of human and zebrafish CFTR orthologs
(University of Missouri--Columbia, 2018)Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels play a critical role in regulating the trans-epithelial movement of water and electrolyte in exocrine tissues and the malfunctions of CFTR result ... -
Structure/function studies of CFTR's pore-forming domain reveal evolutionary divergence between CFTR and ABC transporters
(University of Missouri--Columbia, 2015)Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is the culprit behind Cystic Fibrosis (CF), a genetic disease highly occurs among Caucasians. Studying the structure/function of CFTR chloride channel not only ...