Browsing Graduate School - Theses and Dissertations (MU) by Title "Hypoxia selective DNA alkylating analogs of tirapazamine and Ap-derived DNA interstrand cross-links"
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Hypoxia selective DNA alkylating analogs of tirapazamine and Ap-derived DNA interstrand cross-links
([University of Missouri--Columbia], 2014)Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide, TPZ) is a heterocyclic di-N-oxide that can be selectively reduced enzymatically in oxygen-poor (hypoxic) cells commonly associated with solid tumors. This reduction ...