Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Department "Molecular microbiology and immunology (MU)"
Now showing items 1-20 of 41
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Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ... -
BTrCP is required for HIV-1 Vpu modulation of CD4, GaLV Env, and BST-2/Tetherin
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] The HIV-1 accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, ... -
Comparative study of Human Immunodeficiency Virus type 1 and type 2 single and dual infections
(University of Missouri--Columbia, 2020)Human Immunodeficiency Virus (HIV) type 1 and type 2 are two related lentiviruses that have strikingly divergent features in terms of transmission rates, distribution, pathogenesis, and clinical outcomes. In places where ... -
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by ... -
Development of gene therapy for Duchenne muscular dystrophy heart disease in the MDX mouse model
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a fatal genetic muscle disease with no cure. DMD results from mutations in a critical muscle protein called ... -
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the ... -
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias ... -
Exploring the cell surface : identification and characterization of lipoproteins in Mycoplasma mycoides subsp. mycoides large colony, Mycoplasma mycoides subsp. capri, and Mycoplasma capricolum subsp. capricolum
(University of Missouri--Columbia, 2009)The Mycoplasma mycoides cluster is a group of genetically and antigenically related pathogenic bacteria that infect ruminants. The M. mycoides cluster members that are the focus of this discussion are three caprine pathogens: ... -
Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ... -
Hormonal and genetic regulation of Helicobacter hepaticus-induced intestinal inflammation
(University of Missouri--Columbia, 2010)Inflammatory Bowel Diseases (IBDs) affect millions of people worldwide and are characterized by a chronic intestinal inflammation resulting from a dysregulated immune response to environmental stimuli in genetically ... -
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ... -
The influence of type II cytokines in central tolerance
(University of Missouri--Columbia, 2021)While the genetic elements of many autoimmune conditions have been established, many environmental factors remain a mystery. Exposure to certain infections has been implicated as a possible explanation for the significantly ... -
Influenza virus strategies to regulate S1P-metabolizing enzymes and evade host innate immunity for robust viral replication
(University of Missouri--Columbia, 2021)Viral infection is a complex network of interactions involving the host defending itself against the virus and the virus attempting to subdue host defenses and utilize the cellular machinery to promote its replication. ... -
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)Both HIV-1 and SARS-CoV-2 have been responsible for millions of infectionrelated deaths. Despite advances in treatment for both viruses, neither has a cure, and those living with the disease can unknowingly spread the ... -
Insights into understanding malaria parasite biology : characterization of the Plasmodium protein, MAL13P1.319
(University of Missouri--Columbia, 2011)Malaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. ... -
Interactions between helicobacter-induced inflammation acute changes in the gut microbiota, and colorectal cancer in Smad3-/- mice
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, accounting for 551,269 deaths in 2018 alone. One ... -
Interferon regulatory factor 1 (IRF-1) directs IL-4/IL-13 induced death of neonatal Th1 cells
(University of Missouri--Columbia, 2017)Newborns typically have immune responses that are allergic, due to a predominance of Th2 cells, and lack the ability to respond to vaccines as well as display poor protection against microbes, due to a lack of Th1 cells. ... -
Investigating the deleterious role of B lymphocytes during brucella infection
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a disease known for inducing chronic, often life-long, infections. While it is clear the host immune response fails to clear ... -
Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs ... -
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ...