Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Advisor "Phillips, Charlotte L."
Now showing items 1-8 of 8
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Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ... -
Effects of differential and combinatorial inhibition of myostatin and activin A in the G610 murine model of osteogenesis imperfecta
(University of Missouri--Columbia, 2021)Bone fragility, increased susceptibility to fracture, and low bone mineral density (BMD) are hallmarks of osteogenesis imperfecta (OI), a rare skeletal disorder that arises primarily from defects in the generation, quantity ... -
Glomerular deposition of homotrimeric type I collagen in the COL1A2 deficient mouse
(University of Missouri--Columbia, 2006)Type I collagen is the most abundant structural protein in the body. Type I collagen generally exists as a heterotrimeric protein; however, a homotrimeric isotype of type I collagen has been identified. Our lab currently ... -
Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
(University of Missouri--Columbia, 2009)The Col1a2-deficient (oim) mouse model exclusively synthesizes homotrimeric type I collagen due to the lack of functional pro [alpha] 2(I) collagen chains. The mouse develops a type I collagen glomerulopathy that has ... -
The musculoskeletal effect of exercise and soluble activin receptor type 2b in mouse models of osteogenesis imperfecta
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Osteogenesis Imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen containing tissues, such as ... -
The role of genetic background on the phenotypic severity of the osteogensis imperfecta murine (oim) COLIA2 gene mutation throughout postnatal development
(University of Missouri--Columbia, 2006)Osteogenesis imperfecta (OI) is a diverse disease of type I collagen, the main structural protein in the body. It has been well documented that related individuals harboring the same OI-causing mutation can have very ... -
Role of Proa(2)I collagen chains and collagen crosslinking in thoracic aortic biochemical integrity during aging using the OIM mouse model
(University of Missouri--Columbia, 2006)The extracellular matrix (ECM) is an important constituent for a variety of tissues including vascular tissue in which the ECM maintains aortic wall integrity. An important component of vascular tissue ECM is type I collagen. ... -
Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
(University of Missouri--Columbia, 2021)Osteogenesis imperfecta (OI), also commonly referred to as brittle bone disease, is a heritable connective tissue disorder occurring in roughly 1:15,000 births. OI arises as a result of mutations in the type I collagen ...