Browsing Theses and Dissertations (MU) by Thesis Department "Biochemistry (MU)"
Now showing items 21-40 of 97
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Cryo-EM reveals how adeno-associated virus engages its receptor AAVR and an investigation of the GPR108 ectodomain
(University of Missouri--Columbia, 2022)Adeno-associated virus is one of the leading delivery agents used in gene therapy today. While it is already used in the clinic, some aspects of its basic biology are still not yet fully understood. Only recently in 2017 ... -
Crystal structure of the kelch domain of human keap1
(University of Missouri--Columbia, 2005)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nrf2-Keap1 signal transduction pathway senses oxidative stress and protects eukaryotic cells against oxidative damage and cancer. The transcription ... -
Development of novel breast cancer-targeted spect imaging peptides by phage display
(University of Missouri--Columbia, 2014)Malignancy of the breast is the leading cause of cancer among women and the second leading cause of cancer-related death. Despite implementation of mammograms and breast exams, there still exists a need to detect highly ... -
Development of novel site-specific imaging probes for prostate cancer detection
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Molecular imaging is believed to play a pivotal role in decreasing cancer mortality and improving prognosis in the new era. It relies on molecular ... -
Discovery of epitopes governing MMP-12 specificity for fibrillar substrates : BINDSIght, a method for determining specific sites of substrate surface interactions
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] What determines MMP-12 elastase activity? We have found that the fibrillar substrate specificity of MMP-12 involves surfaces ranging beyond the ... -
Dissecting water stress-induced molecular responses in the maize primary root
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Drought is an important environmental factor limiting crop growth and productivity. With additional pressures arising from population growth and global ... -
Divalent ion-binding and thermal stability studies on rat [beta]-parvalbumin and the evidence of influential distant amino acid residues affecting CD site ion affinity
(University of Missouri--Columbia, 2011)Parvalbumins (PVs) are vertebrate-specific proteins (Mr 12,000), which harbor two EF-hand motifs known as the CD and EF sites. Although the CD and EF sites are typically high-affinity sites, the mammalian [beta]-PV exhibits ... -
DotB : Legionella pneumophila's Dot/Icm Type IV Secretion System's AAA+ motor
(University of Missouri--Columbia, 2023)The Gram-negative bacteria Legionella pneumophila is the causative agent of a severe form of pneumonia known as Legionnaire's Disease. Legionella utilizes its Defect in organelle trafficking/Intracellular multiplication ... -
Effects of differential and combinatorial inhibition of myostatin and activin A in the G610 murine model of osteogenesis imperfecta
(University of Missouri--Columbia, 2021)Bone fragility, increased susceptibility to fracture, and low bone mineral density (BMD) are hallmarks of osteogenesis imperfecta (OI), a rare skeletal disorder that arises primarily from defects in the generation, quantity ... -
Elucidating the roles of the ATP7A copper transporter in cultured cells, tumor growth and metastasis
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is an essential trace metal in all organisms. In humans, copper plays structural and catalytic roles for numerous enzymes and is required for ... -
GABP regulation of the murine GABPa/ATPsynthase coupling factor six and human glutathione reductase promoters
(University of Missouri--Columbia, 2005)GABPa is expressed from a bi-directional promoter expressing ATP synthase coupling factor six (CF6) in the opposite direction. This bi-directional promoter is regulated by GABP, indicating an autoregulation of GABPa. GABP ... -
Glomerular deposition of homotrimeric type I collagen in the COL1A2 deficient mouse
(University of Missouri--Columbia, 2006)Type I collagen is the most abundant structural protein in the body. Type I collagen generally exists as a heterotrimeric protein; however, a homotrimeric isotype of type I collagen has been identified. Our lab currently ... -
Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
(University of Missouri--Columbia, 2009)The Col1a2-deficient (oim) mouse model exclusively synthesizes homotrimeric type I collagen due to the lack of functional pro [alpha] 2(I) collagen chains. The mouse develops a type I collagen glomerulopathy that has ... -
HIV-1 5'UTR RNA structures: connections to infectious lifecycle and potential therapeutic applications
(University of Missouri--Columbia, 2021)Human immunodeficiency virus (HIV) is among the most sinister pathogens plaguing man. As of now, we do not yet have a method to "cure" infection once the virus has integrated into the host genome. It has the highest mutation ... -
Improvement of Biochemistry 2002 through experimental modification and organization of course materials
(University of Missouri--Columbia, 2011)The University of Missouri Biochemistry department offers a variety of courses, each designed with a specific purpose and scheduled to avoid overlap. Biochemistry 2002, sophomore lab, is currently an elective course meant ... -
The influence of mRNA secondary structures on ribosome conformational dynamics
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Synthesizing proteins in the cell is a critical aspect of life. Protein synthesis is a complicated process and involve highly functional machines at a ... -
Informatically-informed biochemical characterization of aptamer-protein complexes
(University of Missouri--Columbia, 2022)Nucleic acid aptamers are single-stranded oligonucleotides that fold into unique three-dimensional shapes that typically bind to targets of interest with high specificity and high affinity. However, a significant limiting ... -
Interaction of secretory protein SecA with its binding partners : lipids and SecB
(University of Missouri--Columbia, 2016)Thirty percent of proteins synthesized in the cytoplasm of E.coli are exported across or into the cytoplasmic membrane to reach their final destinations. The general secretory system exports precursor proteins through the ... -
Investigating changes in the Plasma Membrane proteome and role of USPA-related proteins during plant immune responses
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Food insecurity is a growing global concern as food prices continue to increase. While many factors influence the loss of food production, plant diseases are a contributing factor that result in ... -
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ...