Browsing Theses and Dissertations (MU) by Thesis Department "Pathology and anatomical sciences (MU)"
Now showing items 21-40 of 51
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Dimorphism and integration in the pelves of anthropoid primates
(University of Missouri--Columbia, 2016)The link between obstetric demand (natural selection for birth) and pelvic morphology in anthropoids has remained ambiguous for the past century. Though it is assumed that the dramatic sexual dimorphism seen in modern human ... -
Diversity and evolution of the sauropsid trigeminal sensory system
(University of Missouri--Columbia, 2022)Understanding the evolution of sensory perception is essential in explaining organismal behavior. Organisms using environmental stimuli to navigate their environments, avoid predation, capture prey, and find a mate, have ... -
The driving forces of cranial extra-axial space morphology: age, sex, and drugs
(University of Missouri--Columbia, 2022)Surrounding the brain but contained within the skull is a dynamic organ that functions to physically and chemically maintain the typical functioning of the brain. This organ is usually appreciated only as a series of layered ... -
Epidemiology of non-aureus staphylococcal mastitis in dairy goats
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The hypothesis of this work was that molecular-based speciation and strain-typing methods would help differentiate staphylococcal species with greater ... -
Evaluation of micro-dystrophin based and dystrophin-independent AAV gene therapies for Duchenne Muscular Dystrophy
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Duchenne Muscular dystrophy (DMD) is the most common, progressive childhood muscular dystrophy with an X-linked inheritance. The major cause ... -
Foot and ankle functional morphology in anthropoid primates and Miocene hominoids
(University of Missouri--Columbia, 2020)Locomotion is essential for survival in many taxa. It also varies greatly among organisms, including primates. Studying locomotor diversity in extant and fossil primates requires an understanding of form-function relationships. ... -
Function and evolution of the crocodyliform feeding apparatus
(University of Missouri--Columbia, 2021)The evolution of crocodylians from their suchian ancestors represents one of the great transformations in vertebrate evolution. Modern crocodylians have flat skulls and generate high forces during feeding, but crocodylian ... -
Genetic and microbiota-mediated phenotype variability in the min mouse model of human colorectal cancer
(University of Missouri--Columbia, 2019)Complex diseases develop as a result of genetic predisposition and environmental factors that determine individual risk. Environmental factors such as geographical location, diet, and lifestyle choices shape the gut ... -
Global DNA methylation and gene expression analysis in pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2015)Acute lymphoblastic leukemia (ALL) is a hematological cancer associated with precursor B-cells and is the most common cancer diagnosed in children under the age of 15. Our complete understanding of all mechanisms responsible ... -
Grasping pressures and phalangeal curvature in primates : an experimental in vivo approach
(University of Missouri--Columbia, 2015)Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ... -
Impacts of artificial light and melatonin signaling pathways on behavior and skeletal physiology in mice
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The natural cycles of light and darkness are a major feature of the environment for most species; thus, circadian physiology is rooted in the expectation ... -
Improving ligament tissue scaffold with the use of genipin and gold nanoparticles
(University of Missouri--Columbia, 2020)Decellularized tissue is used for a wide array of tissue injuries with tendon and ligament repair being among the most common. However, despite their frequent use there is concern over the lengthy inflammatory period and ... -
The influence of host genetics, virome, and gut microbiota transfer methods in mouse model reproducibility
(University of Missouri--Columbia, 2021)Gut microbiome (GM), the complex community that combines all bacteria, viruses, protozoa, and fungi located in the gut of human or animal, plays a significant role in host health and disease. Animal model are widely used ... -
Interactions of parvoviruses with the cellular DNA damage response and CTCF
(University of Missouri--Columbia, 2021)Nuclear DNA viruses must be able to simultaneously access cellular factors that aid their life cycle while evading inhibitory factors in order to sustain their expression and replication. Establishment of nuclear sites ... -
Interference with biologic transmission of Anaplasma marginale by targeting the tick-pathogen interface
(University of Missouri--Columbia, 2022)Ticks are globally renowned vectors for numerous zoonoses. Ixodid ticks transmit a variety of viral, bacterial, and protozoan pathogens to their vertebrate hosts. Because of the expansion of the geographic ranges of both ... -
Investigating age- and virulence factor- dependent innate immune activation during neonatal meningitis associated E. coli infection
(University of Missouri--Columbia, 2021)Neonatal meningitis-associated Escherichia coli (NMEC) is a leading cause of early-onset sepsis and meningitis. While current antibiotic protocols have significantly reduced mortality associated with neonatal sepsis and ... -
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oral squamous cell carcinoma (OSCC) is one of the top 10 causes of cancer deaths worldwide, with a 50% 5-year survival rate, necessitating the discovery ... -
Mechanism-based inhibition of matrix metalloproteinase-9 provides neuroprotection in a mouse model of traumatic brain injury
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S. Following an initial mechanical impact, TBI progresses to a secondary ... -
Mechanisms of Alphavirus Midgut dissemination in the Mosquito, Aedes aegypti
(University of Missouri--Columbia, 2018)The research work of this thesis has focused on the midgut escape barrier and the dissemination mechanism of alphaviruses in Ae. aegypti. Primarily, we identified and characterized Ae. aegypti MMPs that are seemingly ... -
Morphological and biomechanical predictions of cranial kinesis in reptile evolution
(University of Missouri--Columbia, 2019)Feeding is a complex behavior that all tetrapods engage in on a regular basis to procure energy and survive. The reptilian feeding apparatus includes many types of feeding behaviors including multiple methods of engaging ...