Browsing Theses and Dissertations (MU) by Thesis Advisor "Duan, Dongsheng"
Now showing items 1-10 of 10
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Automatic four-limb IMU gait analysis in the canine DMD model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) possess ... -
Delineation of Duchenne muscular dystrophy gene therapy using genetically engineered mice
(University of Missouri--Columbia, 2016)Duchenne muscular dystrophy (DMD) is a genetically inherited debilitating muscle disorder affecting young boys due to the loss of dystrophin protein in muscle and the heart. Affected individuals lose their mobility and ... -
Development of gene therapy for Duchenne muscular dystrophy heart disease in the MDX mouse model
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a fatal genetic muscle disease with no cure. DMD results from mutations in a critical muscle protein called ... -
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the ... -
Evaluation of calcium handling and dwarf open reading frame AAV gene therapy in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease. Increased concentrations of cytosolic calcium in dystrophic muscle cells has been implicated in DMD pathogenesis. In healthy muscle, calcium from ... -
Evaluation of micro-dystrophin based and dystrophin-independent AAV gene therapies for Duchenne Muscular Dystrophy
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Duchenne Muscular dystrophy (DMD) is the most common, progressive childhood muscular dystrophy with an X-linked inheritance. The major cause ... -
Four-limb IMU sensors for canine gait analysis
(University of Missouri--Columbia, 2019)Canine models of human musculoskeletal diseases, such as Duchenne muscular dystrophy (DMD), are important translational animal models for developing therapies. Musculoskeletal diseases alter gait performance, and gait ... -
Gene replacement restores the contractile and passive properties of skeletal muscle in murine models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a lethal disease caused by the loss of the dystrophin protein. Loss of mobility is a key clinical presentation in ... -
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ... -
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ...