Browsing Theses and Dissertations (MU) by Thesis Advisor "Jurisson, Silvia S. (Silvia Sabine)"
Now showing items 1-20 of 20
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Applications of radiotracer in plant biology
(University of Missouri--Columbia, 2013)A radioactive tracer (radiotracer) is generally defined as a radioactive isotope that is used as a tracer, which can be followed or tracked within a system of interest. The use of radiotracers involves the substitution of ... -
Arsenic for potential diagnostic imaging and radiotherapy
(University of Missouri--Columbia, 2015)Targeted agents hold promise for non-invasive in vivo imaging, therapy, and monitoring of diseases. Foundational work focused on imaging and therapy of cancer has centered primarily on the use of 18F, 90Y, 99mTc, and 131I ... -
Characterization of acyclic rhodium tetrathioether ligans systems for 105Rh(III)
(University of Missouri--Columbia, 2015)Rhodium-105 is a 36 hr half-life beta emitter potentially useful for radiotherapy. Previously, the reaction of 105 Rh-cholride with a linear tetrathioether ligand resulted in several species. Evaluation of this reaction ... -
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for 105Rh(III)
(University of Missouri--Columbia, 2013)Rhodium-105 is an attractive nuclide for radiotherapeutic applications due to its nuclear properties (566 keV β-, 319 keV [19%], 306 keV [5%]) and the kinetic stability of Rhodium (III) complexes with soft sulfur donor ... -
Investigating Technetium-99m/Rhenium(V)-Cyclized Octreotide analogues using experimental and computational methods
(University of Missouri--Columbia, 2015)Radiolabeled peptides have been of long-standing interest as cancer imaging and radiotherapy agents. Two radioactive isotopes of rhenium are potentially useful for peptide-targeted radiotherapy. Re-186 has a half-life of ... -
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ... -
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ... -
Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ... -
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ... -
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ... -
Radiolabeled bivalent peptide ligands for prostate cancer imaging
(University of Missouri--Columbia, 2015)The diagnosis of prostate cancer in men in US continues to be a burden due to painfulness, non-specificity, and false positives of current methods. The usage of radiolabeled peptides as targeting vectors that selectively ... -
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ... -
Rhenium complexes with O, N, S ligands
(University of Missouri--Columbia, 2006)The main focus of this thesis is the synthesis and characterization of nonradioactive rhenium complexes containing O, N, S ligands. Chapter 2 describes the rhenium labeling of four somatostatin analogues. Confirmation for ... -
Selection of small pretargeting peptides with affinity for radiochelates and separation and purification of radiolanthanides
(University of Missouri--Columbia, 2014)The first objective of this dissertation was to develop metallated chelates with Michael acceptor groups for selecting small peptides from a random phage display library (RPL). The selection is for cysteine bearing peptides, ... -
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of ... -
Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals
(University of Missouri--Columbia, 2007)Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 ... -
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. ... -
Synthesis design and nuclear medicine applications for radiometal, beta and gamma emission, chelated complexes /
(University of Missouri--Columbia, 2017)Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with ... -
Technetium and rhenium (I and V) complexes for radiopharmaceutical applications
(University of Missouri--Columbia, 2016)Technetium and rhenium have radioactive isotopes that are clinically useful for diagnostic (Tc-99m) or therapeutic (Re-186/188) purposes. This makes them attractive candidates for incorporation into pharmaceuticals. One ... -
Technetium from two perspectives : sulfide remediation and schiff base chemistry
(University of Missouri--Columbia, 2015)Two major areas of focus in radiochemistry are environmental and pharmaceutical. This work looks at technetium-99 (Tc-99) chemistry from both viewpoints. The Manhattan Project led to millions of gallons of radioactive ...