Browsing Theses and Dissertations (MU) by Thesis Advisor "Lubahn, Dennis B. (Dennis Bryant), 1954-"
Now showing items 1-4 of 4
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Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes
(University of Missouri--Columbia, 2014)Orphan nuclear receptor Estrogen Receptor Related Receptor Beta (Esrrb) is a transcription factor. Although it was also shown to be important in cancer, little is known about its function in cancer cells and cancer relevant ... -
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities
(University of Missouri--Columbia, 2009)Discovery of new ways to modulate estrogen actions through estrogen receptor is always exciting because of the importance of estrogen and ERs in many human diseases. In this dissertation, we report our discovery of the ... -
Use of simvastatin to inhibit advanced prostate cancer formation in the TRAMP mouse model of prostate cancer
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] A provocative question currently proposed by the NIH is: do statin medications, which lower serum cholesterol, prevent cancer? We hypothesize that ... -
The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ...