Browsing Theses (MU) by Thesis Advisor "Lever, Teresa E."
Now showing items 1-16 of 16
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Characterization of dysphagia in a canine model of late infantile neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Late Infantile Neuronal Ceroid Lipofuscinosis, also known as CLN2, is the most common form of Batten disease in children. Nearly all children with CLN2 ... -
Characterization of dysphagia onset in a mouse model of amyotrophic lateral sclerosis (ALS
(University of Missouri--Columbia, 2017)The primary goal of this study was to characterize dysphagia onset and progression in the low copy number SOD1-G93A (LCN-SOD1) mouse model of ALS. A secondary goal was to determine the effect of serial radiation exposure ... -
Characterizing variable patterns of disease onset and progression in a mouse model of Amyotrophic Lateral Sclerosis (ALS)
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of the current study was to characterize the anatomical site(s) of onset (i.e., specific limb or craniofacial region) and pattern of disease ... -
The effect of isometric tongue exercise in a novel rodent model of dysphagia
(University of Missouri--Columbia, 2019)The tongue plays a crucial role in the swallowing process and impairment can lead to dysphagia, particularly in neurological conditions such as amyotrophic lateral sclerosis (ALS), Parkinson's Disease, and stroke. This ... -
The effect of laryngeal nerve transection on swallowing function in a mouse model
(University of Missouri--Columbia, 2017)Dysphagia is a common postoperative complication of cervical and thoracic surgical procedures, presumably caused by iatrogenic laryngeal nerve injury. It is unknown which laryngeal nerve contributes most to dysphagia and ... -
Effects of menthol on swallowing function in a mouse model of presbyphagia
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to characterize the progression of presbyphagia in our recently established mouse model and investigate the treatment effect ... -
Identification of dysphagia in a transgenic mouse model of amyotrophic lateral sclerosis
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Previous work in our lab has established the SOD1-G93A transgenic mouse as a suitable model for dysphagia (swallowing impairment) in amyotrophic lateral ... -
Impact of selective motor neuron death on hypoglossal motor neuron survival and tongue morphology in a novel model of dysphagia
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive loss of motor neurons and paralysis of the muscles they ... -
Improving the clinical utility of diadochokinetic tasks for early detection of neurological tongue dysfunction
(University of Missouri--Columbia, 2018)Previous work in our lab identified significant differences in tongue function between healthy young (i.e., 20-49 years of age) and healthy old (i.e., 50-89 years of age) participants. While data collection was efficient ... -
Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Unspecified swallowing impairment (dysphagia) was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic ... -
Noninvasive clinical tools to aid in early detection and monitoring of dysphagia in ALS : translating findings from mice to humans
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Previous work in our lab identified lingual dysfunction (i.e., slow lick rate) as the earliest clinical sign of dysphagia in SOD1-G93A transgenic mice, ... -
Standardizing a freely-behaving canine videofluoroscopic swallow study protocol to investigate dysphagia in primary aging and neurological diseases
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to establish a freely-behaving videofluoroscopic swallow study protocol (VFSS) for dogs that permits identification of ... -
Thickening fluids for pediatric patients with Dysphagia: the challenge of achieving safe viscosities
(University of Missouri--Columbia, 2018)Speech-language pathologists (SLPs) at our hospital currently rely on their best clinical judgment to establish a nectar viscosity for bottle feedings because rheological equipment is not readily available. Therefore, ... -
Using the laryngeal adductor reflex to investigate swallowing
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study was to develop a protocol to facilitate identification and quantification of the pathological components of the complex neural ... -
Videofluoroscopic characterization of dysphagia in the low copy number SOD1-G93A transgenic mouse model of ALS
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The goal of this study was to determine if the SOD1-G93A low copy number mouse model of ALS is a suitable model for studying dysphagia (i.e., swallowing ... -
Videofluoroscopic characterization of swallowing impairment in mouse models of amyotrophic lateral sclerosis and advanced aging
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study was to establish a videofluoroscopic swallow study (VFSS) protocol for mice that permits identification of translational biomarkers ...