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Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In recent years a great deal of interest has been focused on the exposure to nitrous acid (HNO2), nitric oxide (NO) and other nitrosating species ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Leinamycin is a structurally novel natural product isolated from the Streptomyces with potent antitumor and antibiotic activity. In a thiol rich ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Determination and analysis of multiphoton excitation emissive species.: I,: Emission of PAHS in acidic medium,: II,: Multiphoton emission of possible PDT agents
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The exploitation of ultrafast laser properties has been recently increasing. Recent research in this lab demonstrated the ability of femtosecond pulses ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of ...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corannulene (C[subscript 20]H[subscript 10]), a polycyclic aromatic hydrocarbon (PAH) is a bowl shaped fullerene fragment. This work involves investigations ...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Supramolecular chemists can be thought of as the architects of the nano-scale world. We are primary concerned with the design and construction of ...
Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. ...
Structural studies of acid phosphatases from pathogenic bacteria
(University of Missouri--Columbia, 2007)
Acid phosphatases are important, ubiquitous, and diverse group of enzymes that catalyze the transfer of phosphoryl from phosphomonoester to water forming inorganic phosphate and alcohol. These enzymes play critical roles ...
Comparison of hyperbranched and dendritic polymers with fluorescent reporter molecules
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hyperbranched polymers containing a core region are a relatively new class of polymers with many similarities to dendrimers, including their proposed ...
Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2008)
One hypothesis that has gained considerable attention in the pathogenesis of Alzheimer's disease (AD) is trace element toxicity, and various elements, including zinc, have become the foci of renewed interest. The first ...
MC-ICP-MS analysis of uranium and plutonium in keratinous samples for the purposes of nuclear forensic and biomarker establishment /
(University of Missouri--Columbia, 2017)
One objective of nuclear forensics is to identify the source of interdicted nuclear materials in order to help ensure the safety and security of special nuclear materials. Since 1995, The International Atomic Energy Agency ...
Technetium and rhenium (I and V) complexes for radiopharmaceutical applications
(University of Missouri--Columbia, 2016)
Technetium and rhenium have radioactive isotopes that are clinically useful for diagnostic (Tc-99m) or therapeutic (Re-186/188) purposes. This makes them attractive candidates for incorporation into pharmaceuticals. One ...
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)
Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ...
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "The field of chemical reaction dynamics is based upon understanding the details of elementary chemical reactions. It seeks to answer fundamental ...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic ...
Docosahexaenoic acid and lipid peroxidation products : insights from studies with microglial cells and mouse brain
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oxidative stress is known to play an important role in neurodegenerative diseases. Microglia are the primary innate immune cells in the central nervous ...