Control of arterial hemoglobin saturation in premature infants using H-infinity synthesis and performance specifications from best clinical practice
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This work details the development of a novel control system for regulating the Arterial Hemoglobin saturation (SpO2) of premature infants. An H-infinity synthesis method was used to derive multiple controllers to cover a large range of parametric uncertainty in the model. Performance specifications were defined using manual control protocols, which are clinically proven to reduce the rate of Retinopathy of Prematurity (ROP) in the target patients. The controllers were tested using previously validated models and shown to meet the robust stability and performance specifications. In order to switch between controllers and adapt to the changing physiology of the patients a genetic algorithm was modified and tested. This algorithm was proven to adequately track changing model parameters and select an appropriate robust controller for providing closed loop control. In addition a physical prototype was designed and built to facilitate automatic control of FiO2 during clinical tests of the control algorithms.