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dc.contributor.advisorFales, Rogereng
dc.contributor.authorQuigley, Danieleng
dc.contributor.otherUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2013 Theseseng
dc.date.issued2013eng
dc.date.submitted2013 Summereng
dc.descriptionJuly 2013.eng
dc.descriptionA Thesis presented to the Faculty of the Graduate School University of Missouri--Columbia In Partial Fulfillment of the Requirements of the Degree Master of Science.eng
dc.descriptionAdvisor: Dr. Roger Fales.eng
dc.description.abstractThis work details the development of a novel control system for regulating the Arterial Hemoglobin saturation (SpO2) of premature infants. An H-infinity synthesis method was used to derive multiple controllers to cover a large range of parametric uncertainty in the model. Performance specifications were defined using manual control protocols, which are clinically proven to reduce the rate of Retinopathy of Prematurity (ROP) in the target patients. The controllers were tested using previously validated models and shown to meet the robust stability and performance specifications. In order to switch between controllers and adapt to the changing physiology of the patients a genetic algorithm was modified and tested. This algorithm was proven to adequately track changing model parameters and select an appropriate robust controller for providing closed loop control. In addition a physical prototype was designed and built to facilitate automatic control of FiO2 during clinical tests of the control algorithms.eng
dc.description.bibrefIncludes bibliographical references (pages 84-86).eng
dc.format.extent1 online resource (vi, 86 pages) : illustrations (some color)eng
dc.identifier.oclc897475685eng
dc.identifier.urihttps://hdl.handle.net/10355/40210
dc.identifier.urihttps://doi.org/10.32469/10355/40210eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2013 Freely available theses (MU)eng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.source.originalSubmitted by the University of Missouri--Columbia Graduate Schooleng
dc.subject.lcshOxygen therapy for premature infantseng
dc.subject.lcshRetrolental fibroplasiaeng
dc.subject.lcshOxygen in the body -- Measurementeng
dc.subject.lcshOxygen -- Physiological effecteng
dc.subject.lcshGenetic algorithmseng
dc.titleControl of arterial hemoglobin saturation in premature infants using H-infinity synthesis and performance specifications from best clinical practiceeng
dc.typeThesiseng
thesis.degree.disciplineMechanical and aerospace engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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