dc.contributor.advisor | Schachtman, Todd R. | eng |
dc.contributor.author | Klakotskaia, Diana | eng |
dc.date.issued | 2013 | eng |
dc.date.submitted | 2013 Summer | eng |
dc.description | July 2013. | eng |
dc.description | A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Masters of Arts. | eng |
dc.description | Thesis supervisor: Dr. Todd Schachtman. | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Metabotropic glutamate (mGlu) receptors are known to mediate learning and memory. Although evidence indicates a role for mGlu receptors (e.g., mGlu5) in conditioned taste aversion (CTA), a complete understanding of the subtype-specific involvement of mGlu receptors in this associative learning task remains to be determined. The current study examined the effects of (1R,4R,5S,6R)-4-Amino-2- oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), a selective group II mGlu receptor agonist, and cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (VU0155041), a mGlu4 receptor selective positive allosteric modulator, on the acquisition of CTA using male Sprague-Dawley rats. It was found that systemic injections of LY379268 prior to the conditioning trial decreased the acquisition of CTA on later test trials, while injections of VU0155041 prior to the conditioning trial had no effect on the acquisition of CTA. | eng |
dc.description.bibref | Includes bibliographical references (pages 23-32). | eng |
dc.format.extent | 1 online resource (vii, 32 pages) : illustrations | eng |
dc.identifier.oclc | 897820981 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/40222 | |
dc.identifier.uri | https://doi.org/10.32469/10355/40222 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campuses of the University of Missouri. | eng |
dc.source | Submitted by the University of Missouri--Columbia Graduate School | eng |
dc.subject.lcsh | Taste -- Animal models | eng |
dc.subject.lcsh | Aversion -- Animal models | eng |
dc.subject.lcsh | Conditioned response -- Animal models | eng |
dc.subject.lcsh | Paired-association learning -- Animal models | eng |
dc.subject.lcsh | Glutamic acid -- Receptors -- Animal models | eng |
dc.title | The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Psychological sciences (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Masters | eng |
thesis.degree.name | M.A. | eng |