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dc.contributor.advisorSchachtman, Todd R.eng
dc.contributor.authorKlakotskaia, Dianaeng
dc.date.issued2013eng
dc.date.submitted2013 Summereng
dc.descriptionJuly 2013.eng
dc.descriptionA Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Masters of Arts.eng
dc.descriptionThesis supervisor: Dr. Todd Schachtman.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Metabotropic glutamate (mGlu) receptors are known to mediate learning and memory. Although evidence indicates a role for mGlu receptors (e.g., mGlu5) in conditioned taste aversion (CTA), a complete understanding of the subtype-specific involvement of mGlu receptors in this associative learning task remains to be determined. The current study examined the effects of (1R,4R,5S,6R)-4-Amino-2- oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), a selective group II mGlu receptor agonist, and cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (VU0155041), a mGlu4 receptor selective positive allosteric modulator, on the acquisition of CTA using male Sprague-Dawley rats. It was found that systemic injections of LY379268 prior to the conditioning trial decreased the acquisition of CTA on later test trials, while injections of VU0155041 prior to the conditioning trial had no effect on the acquisition of CTA.eng
dc.description.bibrefIncludes bibliographical references (pages 23-32).eng
dc.format.extent1 online resource (vii, 32 pages) : illustrationseng
dc.identifier.oclc897820981eng
dc.identifier.urihttps://hdl.handle.net/10355/40222
dc.identifier.urihttps://doi.org/10.32469/10355/40222eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.sourceSubmitted by the University of Missouri--Columbia Graduate Schooleng
dc.subject.lcshTaste -- Animal modelseng
dc.subject.lcshAversion -- Animal modelseng
dc.subject.lcshConditioned response -- Animal modelseng
dc.subject.lcshPaired-association learning -- Animal modelseng
dc.subject.lcshGlutamic acid -- Receptors -- Animal modelseng
dc.titleThe effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversioneng
dc.typeThesiseng
thesis.degree.disciplinePsychology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.A.eng


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