Photo-biomodulation and soybean isoflavones on amyloid-beta peptide-induced oxidative stress and inflammation
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is a chronic neurodegenerative disorder, and the aggregation of amyloid-[beta]-peptide (A[beta]) is recognized as one of the prevailing pathology of AD. There is a large body of evidence demonstrate that A[beta] can induce the production of reactive oxygen species (ROS) and pro-inflammatory factors, like interleukin-1[beta] (IL-1[beta]) and inducible nitric-oxide synthase (iNOS). In this study, two different treatment strategies have been examined on the effect of inhibiting A[beta]-induced ROS and inflammation, including photo-biomodulation with 785 nm laser light and soybean isoflavones treatment. In the present study, both laser light treatment and soybean isoflavones treatment showed the ability to suppress A[beta]-induced oxidative stress and inflammation response. Furthermore, the anti-amyloidogenesis effects of soybean isoflavones have been discussed in this thesis.
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