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dc.contributor.authorChoo, Jinaeng
dc.contributor.authorShin, Choleng
dc.contributor.authorBarinas-Mitchell, Emmaeng
dc.contributor.authorMasaki, Kamaleng
dc.contributor.authorWillcox, Bradley J.eng
dc.contributor.authorSeto, Todd Beng
dc.contributor.authorUeshima, Hirotsugu, 1943-eng
dc.contributor.authorLee, Sungheeeng
dc.contributor.authorMiura, Katsuyukieng
dc.contributor.authorVenkitachalam, Lakshmieng
dc.contributor.authorMackey, Rachel Heng
dc.contributor.authorEvans, Rhobert Weng
dc.contributor.authorKuller, Lewis H.eng
dc.contributor.authorSutton-Tyrrell, Kimeng
dc.contributor.authorSekikawa, Akiraeng
dc.date.issued2014-01-13eng
dc.description.abstractAbstract Background Both carotid-femoral (cf) pulse wave velocity (PWV) and brachial-ankle (ba) PWV employ arterial sites that are not consistent with the path of blood flow. Few previous studies have reported the differential characteristics between cfPWV and baPWV by simultaneously comparing these with measures of pure central (aorta) and peripheral (leg) arterial stiffness, i.e., heart-femoral (hf) PWV and femoral-ankle (fa) PWV in healthy populations. We aimed to identify the degree to which these commonly used measures of cfPWV and baPWV correlate with hfPWV and faPWV, respectively, and to evaluate whether both cfPWV and baPWV are consistent with either hfPWV or faPWV in their associations with cardiovascular (CV) risk factors. Methods A population-based sample of healthy 784 men aged 40–49 (202 white Americans, 68 African Americans, 202 Japanese-Americans, and 282 Koreans) was examined in this cross-sectional study. Four regional PWVs were simultaneously measured by an automated tonometry/plethysmography system. Results cfPWV correlated strongly with hfPWV (r = .81, P < .001), but weakly with faPWV (r = .12, P = .001). baPWV correlated moderately with both hfPWV (r = .47, P < .001) and faPWV (r = .62, P < .001). After stepwise regression analyses with adjustments for race, cfPWV shared common significant correlates with both hfPWV and faPWV: systolic blood pressure (BP) and body mass index (BMI). However, BMI was positively associated with hfPWV and cfPWV, and negatively associated with faPWV. baPWV shared common significant correlates with hfPWV: age and systolic BP. baPWV also shared the following correlates with faPWV: systolic BP, triglycerides, and current smoking. Conclusions Among healthy men aged 40 – 49, cfPWV correlated strongly with central PWV, and baPWV correlated with both central and peripheral PWVs. Of the CV risk factors, systolic BP was uniformly associated with all the regional PWVs. In the associations with factors other than systolic BP, cfPWV was consistent with central PWV, while baPWV was consistent with both central and peripheral PWVs.eng
dc.description.versionPeer Reviewedeng
dc.identifier.citationBMC Cardiovascular Disorders. 2014 Jan 13;14(1):5eng
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2261-14-5eng
dc.identifier.urihttp://hdl.handle.net/10355/41080eng
dc.rights.holderJina Choo et al.; licensee BioMed Central Ltd.eng
dc.titleRegional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: a cross-sectional population-based studyeng
dc.typeJournal Articleeng


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