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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2005 Dissertations (MU)
    • 2005 MU dissertations - Freely available online
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    Flourescent molecular rotors as mechanosensors in biofluids

    Akers, Walter John, 1975-
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    Date
    2005
    Format
    Thesis
    Metadata
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    Abstract
    Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. Biofluid viscosity measurements by conventional methods are complicated by protein adherence to surfaces and formation of air-surface layers. The presented work demonstrates the usefulness of fluorescence viscometry using molecular rotors dissolved in aqueous solutions and blood plasma. The precision of fluorescence viscometry is compared with that of a state-of-the-art cone and plate viscometer. The interaction of molecular rotors in solution with blood plasma proteins is reported. The viscosity sensitivity of surfaceimmobilized molecular rotors to glass nanoparticles and optical fibers is also investigated. Conclusions: fluorescence viscometry using molecular rotors promises to be a powerful new method for biofluid viscosity measurement, delivering fast readout for microliter volume samples.
    URI
    https://hdl.handle.net/10355/4114
    https://doi.org/10.32469/10355/4114
    Degree
    Ph. D.
    Thesis Department
    Biological engineering (MU)
    Collections
    • Biological Engineering electronic theses and dissertations - Engineering (MU)
    • Biological Engineering electronic theses and dissertations - CAFNR (MU)
    • 2005 MU dissertations - Freely available online

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