dc.contributor.advisor | Haidekker, Mark A., 1963- | eng |
dc.contributor.author | Akers, Walter John, 1975- | eng |
dc.date.issued | 2005 | eng |
dc.date.submitted | 2005 Fall | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Title from title screen of research.pdf file (viewed on October 19, 2007) | eng |
dc.description | Vita. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | Thesis (Ph. D.) University of Missouri-Columbia 2005. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- Biological engineering. | eng |
dc.description.abstract | Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. Biofluid viscosity measurements by conventional methods are complicated by protein adherence to surfaces and formation of air-surface layers. The presented work demonstrates the usefulness of fluorescence viscometry using molecular rotors dissolved in aqueous solutions and blood plasma. The precision of fluorescence viscometry is compared with that of a state-of-the-art cone and plate viscometer. The interaction of molecular rotors in solution with blood plasma proteins is reported. The viscosity sensitivity of surfaceimmobilized molecular rotors to glass nanoparticles and optical fibers is also investigated. Conclusions: fluorescence viscometry using molecular rotors promises to be a powerful new method for biofluid viscosity measurement, delivering fast readout for microliter volume samples. | eng |
dc.identifier.merlin | b60595474 | eng |
dc.identifier.oclc | 174965401 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/4114 | |
dc.identifier.uri | https://doi.org/10.32469/10355/4114 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.source | Submitted by University of Missouri--Columbia Graduate School. | eng |
dc.subject.lcsh | Blood -- Viscosity | eng |
dc.subject.lcsh | Biomechanics | eng |
dc.subject.lcsh | Body fluid flow -- Measurement | eng |
dc.title | Flourescent molecular rotors as mechanosensors in biofluids | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Biological engineering (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |