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dc.contributor.advisorHaidekker, Mark A., 1963-eng
dc.contributor.authorAkers, Walter John, 1975-eng
dc.date.issued2005eng
dc.date.submitted2005 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on October 19, 2007)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2005.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological engineering.eng
dc.description.abstractMany disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. Biofluid viscosity measurements by conventional methods are complicated by protein adherence to surfaces and formation of air-surface layers. The presented work demonstrates the usefulness of fluorescence viscometry using molecular rotors dissolved in aqueous solutions and blood plasma. The precision of fluorescence viscometry is compared with that of a state-of-the-art cone and plate viscometer. The interaction of molecular rotors in solution with blood plasma proteins is reported. The viscosity sensitivity of surfaceimmobilized molecular rotors to glass nanoparticles and optical fibers is also investigated. Conclusions: fluorescence viscometry using molecular rotors promises to be a powerful new method for biofluid viscosity measurement, delivering fast readout for microliter volume samples.eng
dc.identifier.merlinb60595474eng
dc.identifier.oclc174965401eng
dc.identifier.urihttps://hdl.handle.net/10355/4114
dc.identifier.urihttps://doi.org/10.32469/10355/4114eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subject.lcshBlood -- Viscosityeng
dc.subject.lcshBiomechanicseng
dc.subject.lcshBody fluid flow -- Measurementeng
dc.titleFlourescent molecular rotors as mechanosensors in biofluidseng
dc.typeThesiseng
thesis.degree.disciplineBiological engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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