What is the best age to start vitamin D supplementation to prevent rickets in breastfed newborns?
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Evidence-based answer: It’s unclear what age is best to start vitamin D supplementation because no comparison studies exist. That said, breastfed infants who take vitamin D beginning at 3 to 5 days of life don’t develop rickets (strength of recommendation SOR]: B, randomized trial). Starting infants on vitamin D supplementation at one to 36 months of age reduces the risk of rickets (SOR: B, a controlled and a randomized controlled trial).
Journal of Family Practice, 62(12) 2013: 755, 763.