How long do you continue bisphosphonate therapy for osteoporosis?
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Evidence-Based Answer: At 10-year follow-up, patients who stopped bisphosphonates after 5 years have similar nonvertebral fracture rates as patients who remain on bisphosphonates for a 10 full years; however, they have greater changes in bone mineral density (BMD) and their risk of clinical vertebral fractures may be higher (SOR: B, large RCT). Patients who take bisphosphonates for 3 years will have a decrease in BMD after discontinuation for 1 year, but their mean BMD will still be higher than before bisphosphonate therapy was started (SOR: C, diseaseoriented outcome).
Evidence-based practice 16, no. 10 (2013): E08