What botanicals are safe and effective for the estrogen deficiency symptoms of menopause?
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Evidence-Based Answer: Soy may reduce hot flash frequency (SOR: B, inconsistent RCTs). Red clover and black cohosh are not effective in treating vasomotor symptoms of estrogen deficiency (SOR: A, systematic review and RCTs). Safety has been shown with the use of some botanicals for up to 1 year (SOR: C, underpowered RCT).
Evidence Based Practice 16(10): 06