Are any iron supplement formulations better tolerated than ferrous sulfate?
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Are any iron supplement formulations better tolerated than ferrous sulfate? Evidence-Based Answer: Iron (III) polymaltose complex (IPC) has fewer gastrointestinal adverse effects than ferrous sulfate (FeSO4) (SOR: A, meta-analysis). Women report fewer adverse effects with iron protein succinylate (IPS) than with FeSO4, but men report no difference (SOR: B, meta-analysis of small RCTs). Neither sustained-release FeSO4 nor carbonyl iron is better tolerated than rapidly disintegrated FeSO4 (SOR: B, comparison RCTs).
Evidence Based Practice 16(10): E-12