What is the best test for Lyme disease?
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What is the best test for Lyme disease? Evidence-Based Answer: If a patient develops erythema migrans after a tick bite in an endemic area, no testing is required. Simply treat the patient. If the diagnosis of Lyme disease is uncertain, obtain a sensitive enzyme-linked immunosorbent assay (ELISA) followed by the more specific immunoblot (Western blot) if the ELISA is positive. A negative ELISA obtained within 1 month of exposure should be repeated in 2 weeks if the patient remains symptomatic (SOR:B, diagnostic cohort and evidence-based guidelines)
Evidence Based Practice 16(10): E-02-E-03