What is the safest first-line oral hypoglycemic agent for geriatric patients with new-onset type 2 diabetes?
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What is the safest first-line oral hypoglycemic agent for geriatric patients with new-onset type 2 diabetes? Evidence-Based Answer: Which oral hypoglycemic agent is safest for geriatric patients is unclear, partly because the adverse effect profiles differ. Dipeptidyl peptidase-4 inhibitors (sitagliptin and saxagliptin) cause hypoglycemia at a rate similar to placebo. Metformin causes less hypoglycemia than sulfonylureas, but is associated with higher rates of gastrointestinal distress. Thiazolidinediones also cause less hypoglycemia than sulfonylureas, but are associated with volume expansion (SOR: A, systematic reviews).
Evidence Based Practice 17(2): E-10-E-11