What is the most effective treatment for hirsutism in a patient with polycystic ovarian syndrome (PCOS)?
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What is the most effective treatment for hirsutism in a patient with polycystic ovarian syndrome (PCOS)? Bottom line: Effective single treatments for hirsutism in patients with PCOS include metformin, oral contraceptives (OCs), finasteride, flutamide, spironolactone, and thiazolidinediones. Thinner patients and those with more hirsutism at baseline tend to have better responses. Combination therapy with metformin and OCs or with eflornithine cream and laser treatment may be more effective than single therapy (SOR: A, systematic reviews of RCTs and evidence-based guideline). Weight reduction in obese patients is associated with decreased hirsutism (SOR: B, evidence-based guideline).
Evidence Based Practice 17(3):14