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dc.contributor.advisorWeisman, Gary A.eng
dc.contributor.advisorLim, Robert W.eng
dc.contributor.authorSchrader-Ratchford, Ann Marieeng
dc.date.issued2005eng
dc.date.submitted2005 Springeng
dc.description"May 2005"eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVita.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- pharmacology.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2005.eng
dc.descriptionIncludes bibliographical references.eng
dc.description.abstractSjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y₂ nucleotide receptors for extracellular ATP and UTP are up-regulated in response to stress or injury in a variety of tissues including submandibular glands (SMGs). Therefore, our objective was to assess whether P2Y₂ receptor expression is up-regulated in SMGs of the NOD.B10 mouse model of SS, and to determine the function of P2Y₂Rs in salivary gland tissue. Our data indicate that P2Y₂Rs are up-regulated in SMGs of the NOD.B10 mice, and this up-regulation increases as the disease progresses. Moreover, data obtained using a human submandibular gland cell line, demonstrate that P2Y₂Rs activate a signaling pathway leading to gene transcription via at least two distinct mechanisms. These findings suggest that regulation of P2Y₂Rs is likely to be an important therapeutic target for various diseases.eng
dc.identifier.merlinb55147471eng
dc.identifier.oclc65430529eng
dc.identifier.urihttps://hdl.handle.net/10355/4189
dc.identifier.urihttps://doi.org/10.32469/10355/4189eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations.eng
dc.subject.meshSubmandibular Glandeng
dc.subject.meshModels, Animaleng
dc.subject.meshReceptors, Purinergic P2eng
dc.titleP2Y�?? nucleotide receptor up-regulation and function in submandibular gland epitheliumeng
dc.typeThesiseng
thesis.degree.disciplinePharmacology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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