dc.contributor.advisor | Weisman, Gary A. | eng |
dc.contributor.advisor | Lim, Robert W. | eng |
dc.contributor.author | Schrader-Ratchford, Ann Marie | eng |
dc.date.issued | 2005 | eng |
dc.date.submitted | 2005 Spring | eng |
dc.description | "May 2005" | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Vita. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- pharmacology. | eng |
dc.description | Thesis (Ph. D.) University of Missouri-Columbia 2005. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description.abstract | Sjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y₂ nucleotide receptors for extracellular ATP and UTP are up-regulated in response to stress or injury in a variety of tissues including submandibular glands (SMGs). Therefore, our objective was to assess whether P2Y₂ receptor expression is up-regulated in SMGs of the NOD.B10 mouse model of SS, and to determine the function of P2Y₂Rs in salivary gland tissue. Our data indicate that P2Y₂Rs are up-regulated in SMGs of the NOD.B10 mice, and this up-regulation increases as the disease progresses. Moreover, data obtained using a human submandibular gland cell line, demonstrate that P2Y₂Rs activate a signaling pathway leading to gene transcription via at least two distinct mechanisms. These findings suggest that regulation of P2Y₂Rs is likely to be an important therapeutic target for various diseases. | eng |
dc.identifier.merlin | b55147471 | eng |
dc.identifier.oclc | 65430529 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/4189 | |
dc.identifier.uri | https://doi.org/10.32469/10355/4189 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.subject.mesh | Submandibular Gland | eng |
dc.subject.mesh | Models, Animal | eng |
dc.subject.mesh | Receptors, Purinergic P2 | eng |
dc.title | P2Y[subscript 2] nucleotide receptor up-regulation and function in submandibular gland epithelium | eng |
dc.title.alternative | P2Y2 nucleotide receptor up-regulation and function in submandibular gland epithelium | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Medical Pharmacology and Physiology (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |