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dc.contributor.advisorLee, Jameseng
dc.contributor.authorYang, Xiaoguangeng
dc.date.issued2010eng
dc.date.submitted2010 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on April 23, 2014).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVitaeng
dc.description.abstractThe overall goal of this thesis work is to study the effects of biomodulations on Alzheimer's disease (AD) related cellular pathways, using biophysical and photobiological methods, including secretory phospholipase A2, various fatty acids treatments and low energy light irradiation. By increasing membrane fluidity in neuronal cells, secretory phospholipase A2 and unsaturated fatty acids with 4 or more double bonds are able to increase the secretion of neuroprotective and neurotrophic [alpha]-secretase-cleaved soluble APP (sAPP[alpha]). Low energy laser at 632.8 nm is able to suppress amyloid-[beta] peptide (A[beta])-induced oxidative and inflammatory responses in primary astrocytes, suggesting it has neuroprotective effects against oxidative stress and inflammation in AD. This thesis work provides insights into potential therapeutic treatments and prevention of AD.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentvii, 157 pageseng
dc.identifier.urihttps://hdl.handle.net/10355/41900
dc.identifier.urihttps://doi.org/10.32469/10355/41900eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subjectAlzheimer's diseaseeng
dc.subjectMembrane fluidityeng
dc.subjectAPP processingeng
dc.subjectsPLA2eng
dc.subjectFatty acidseng
dc.subjectLow energy lasereng
dc.subject.FASTAlzheimer's disease -- Researcheng
dc.subject.FASTArachidonic acideng
dc.subject.FASTMembranes (Biology) -- Fluidityeng
dc.subject.FASTFatty acidseng
dc.titleBiophysical and photobiological modulations of cellular pathways in Alzheimer's diseaseeng
dc.typeThesiseng
thesis.degree.disciplineBiological engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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