Browsing 2009 MU dissertations - Access restricted to MU by Identifier "https://hdl.handle.net/10355/9687"
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Adaptive optimal design with application to a two drug combination trial based on efficiency-toxicity response
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The first part of this dissertation develops an adaptive optimal design for dose-finding with combination therapies that accounts for both efficacy ...