What's the best treatment for pyogenic granuloma?
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Simple surgical excision is associated with a low risk of recurrence, but often leaves a visible scar. Curettage or shave excision, with cautery, is more likely to succeed in 1 session than cryotherapy; both may leave a smaller scar than surgery. Laser therapy, which may require multiple sessions, and sclerotherapy may be least likely to cause visible scarring (strength of recommendation [SOR]: C, small cohort studies and case series). Untreated pyogenic granulomas regress spontaneously within 6 to 18 months with some risk of scarring (SOR: C, a subset of patients in a retrospective cohort study).
Journal of Family Practice, 59(1) 2010: 40+.