[-] Show simple item record

dc.contributor.advisorSchachtman, Todd R.eng
dc.contributor.authorWalker, Jennifer M., 1985-eng
dc.date.issued2013eng
dc.date.submitted2013 Falleng
dc.description.abstractPrevious work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease pathology, reduces cognitive impairments; however, approximately 1-month of exercise started at 80-days failed to provide cognitive improvements for male mice. Additionally, research has shown that EGCG, a botanical polyphenol, can reduce amyloid-beta levels, mitigate oxidative stress and reduce some of the cognitive impairments associated with Alzheimer's disease in the Tg2576 murine model; however, oral administration of EGCG had not been yet evaluated in the TgCRND8 strain. The present study investigated the effects of 4-months of exercise treatment, implemented at the beginning of pathology development (2-months of age), in conjunction with the effects of EGCG treatment on: 1) behavioral measures: learning and memory performance in the Barnes maze, nest building, the open-field, anxiety in the light-dark box, and 2) soluble, amyloid-beta levels in the cortex and hippocampus. Untreated Tg mice showed deficits in nest building behaviors, as well as poor spatial learning in the Barnes maze. Four-months of EGCG and exercise treatment reversed nest building and spatial learning deficits, and lowered soluble, Ab1-42 levels in the cortex of Tg animals. This research was supported by NIH grant funding (2P01 AG18357).eng
dc.description.bibrefIncludes bibliographical references (pages 52-64).eng
dc.format.extent1 online resource (viii, 66 pages) : color illustrationseng
dc.identifier.oclc896176517eng
dc.identifier.urihttps://hdl.handle.net/10355/42989
dc.identifier.urihttps://doi.org/10.32469/10355/42989eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2013 Freely available dissertations (MU)eng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.source.originalSubmitted by the University of Missouri--Columbia Graduate School.eng
dc.subjectTgCRND8 mouse modeleng
dc.subject.lcshAlzheimer's diseaseeng
dc.subject.lcshAlzheimer's disease -- Animal modelseng
dc.subject.lcshExercise -- Physiological aspectseng
dc.subject.lcshEpigallocatechin gallate -- Therapeutic useeng
dc.subject.lcshAmyloid beta-protein -- Physiological effecteng
dc.titleEGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's diseaseeng
dc.typeThesiseng
thesis.degree.disciplinePsychology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record