For patients with vitamin D deficiency, what is the appropriate replacement dose?
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For patients with vitamin D deficiency, what is the appropriate replacement dose? Evidence-Based Answer: Both ergocalciferol (vitamin D2) 1,000 IU and cholecalciferol (vitamin D3) 1,000 IU are equally effective in raising 25-hydroxyvitamin D levels [25(OH) D]. Oral replacement with 50,000 IU weekly for 6 weeks is more effective than parental replacement with a single dose of 300,000 IU at 3 months out, with no difference at 6 months (SOR: C, disease-oriented evidence).
Evidence Based Practice 17(5): E-13