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dc.contributor.advisorKanaley, Jill A. (Jill Ann)eng
dc.contributor.authorNyhoff, Lauryneng
dc.date.issued2013eng
dc.date.submitted2013 Falleng
dc.description"December 2013."eng
dc.description"A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia Submitted in partial fulfillment of the requirements for the degree of Master of Science in Exercise Physiology in the Graduate School of University of Missouri--Columbia."eng
dc.descriptionThesis advisor: Professor Jill Kanaley, Ph.D.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this study was to determine the incretin response to an acute continuous, moderate intensity (ModEx) and high-intensity interval (IntEx) exercise bout in obese women, and how previous exercise affects the glycemic and incretin response to a subsequent dinner meal. Sedentary, obese women (BMI>30kg/m2 ; 18-35 yr) participated in three conditions in a randomized, counterbalanced design: 1) No exercise/rest (NoEx), 2) continuous, moderate intensity exercise at 55% VO2max (ModEx), and 3) high-intensity aerobic interval exercise at 4 min 80% VO2max/3 min 50% VO2max (IntEx), followed by a standardized mixed dinner meal (800kcal; 65% CHO, 20% fat, 15% protein). Blood was sampled every 10 min for the first 160 min and then every 30 min for the final 2 h of the study day. Samples were analyzed for glucose, lactate, insulin, glucagon, GLP-1, GIP, and C-Peptide. Lactate concentrations increased during exercise in ModEx (6.2±0.7 mg/dL) and even greater in IntEx (15.4±2.5 mg/dL) conditions compared to NoEx (3.7±0.2 mg/dL) (p=0.01; p=0.001, respectively) which persisted into recovery (p=0.01). Glucose concentrations were not different between groups during exercise (p=0.38). Mean GIP and GLP-1 was not different between groups during exercise (p>0.05), but during recovery, GLP-1 concentrations were higher in ModEx condition compared to NoEx (p=0.03). In response to a mixed dinner meal, insulin and C-peptide iAUC was lower in ModEx condition compared to NoEx (p=0.002; p=0.005, respectively). No differences between groups were detected for glucose, GIP, GLP-1, hepatic insulin extraction, insulin secretion, or insulin sensitivity following the meal. Regardless of intensity, GLP-1 and GIP concentrations were increased during the latter stages of exercise, accompanied by a decrease in plasma insulin concentrations; opposite of the postprandial insulinotropic response previously associated with the incretin hormones. Insulin concentrations were reduced more so in the ModEx condition which may be attrieng
dc.description.bibrefIncludes bibliographical references (pages 58-63).eng
dc.format.extent1 online resource (iv, 73 pages) : illustrationseng
dc.identifier.oclc899741670eng
dc.identifier.urihttps://hdl.handle.net/10355/43159
dc.identifier.urihttps://doi.org/10.32469/10355/43159eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.source.originalSubmitted by the University of Missouri--Columbia Graduate Schooleng
dc.titleIncretin response to acute exercise of differing intensities in obese womeneng
dc.typeThesiseng
thesis.degree.disciplineExercise physiology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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