Browsing 2014 UMKC Dissertations - Freely Available Online by Thesis Department "Molecular Biology and Biochemistry (UMKC)"
Now showing items 1-10 of 10
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Analyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
(2014)The highly dynamic and nonrandom spatial organization of the eukaryotic nucleus plays an important role in the regulation of gene expression. For example, in S. cerevisiae, several conditionally expressed genes relocate ... -
Bayesian Change Point Analysis of Copy Number Variants Using Human Next Generation Sequencing Data
(2014)Read count analysis is the principal strategy implemented in detection of copy number variants using human next generation sequencing (NGS) data. Read count data from NGS has been demonstrated to follow non homogeneous ... -
Determining the differential roles of the dock family of GEFs in drosophila development
(2015-05-19)The evolutionarily conserved Dock proteins function as unconventional guanine nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell motility) proteins, Dock-ELMO complexes activate the Rho family ... -
Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
(2014)C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence ... -
Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
(2014-09-30)Archaea are a distinct evolutionary domain of microorganisms that contain isoprenoids in ether linkages to glycerol rather than the ester linked fatty acids that characterize membranes of bacteria or eukaryotes. Radiolabeling ... -
Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)The research presented in this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. ... -
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
(2015-06-02)Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway ... -
Mating Type Specific Roles During The Sexual Cycle Of Phycomyces Blakesleeanus
(2014)Phycomyces blakesleeanus is a filamentous fungus that belongs in the order Mucorales. It can propagate through both sexual and asexual reproduction. The asexual structures of Phycomyces called sporangiophores have served ... -
Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
(2015-05-26)The innate immune system, also known as natural or non-specific immune system, is conserved from insects to humans. The insect innate immune system is composed of humoral and cellular components. Insect humoral responses ... -
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
(2014)Expansion of high-throughput sequencing technology has increased our understanding in the importance of pervasive transcription and the resulting indispensable molecules, noncoding RNAs (ncRNAs). A significant effort has ...