On the role of IL-13R[alpha]1 on basophils, dendritic cells and macrophages in neonatal and adult immune systems modulation
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] IL-13R[alpha]1 is a component of the heterodimeric receptor complex formed by IL-4R[alpha] and IL-13R[alpha]1. The receptor is mainly expressed on cells derived from myeloid progenitors such as macrophage and dendritic cells with the exception of neonatal Th1 cells. In our studies we find significant but opposing roles played by IL-13R[alpha]1 on basophils and dendritic cells in modulating neonatal immunity. In fact, in the absence of functional IL-13R[alpha]1, neonatal immunity is reversely skewed towards the Th1 responses. We attribute this to a lower basophil frequency, and their reduced ability to make the Th2 driving cytokine IL-4 combined with strong production of the Th1 polarizing cytokine IL-12 by dendritic cells. Moreover, we show that basophils in neonates function as antigen presenting cells as well as provide initial IL-4 to drive Th2 cell differentiation. In addition, when we examined the functional roles played by this receptor on macrophages, we found that receptor expression is associated with the M2 but not the M1 subset of macrophages. Interestingly, the heteroreceptor complex not only defined functions of macrophage but also controlled the differentiation of these cells from BM progenitors. Thus, we suggest unique but undefined roles of IL-13R[alpha]1 on murine basophils, dendritic cell and macrophages.
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