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dc.contributor.advisorLever, Susan Z., 1952-eng
dc.contributor.authorAkgun, Zeynep, 1975-eng
dc.date.issued2006eng
dc.date.submitted2006 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on July 30, 2006).eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstractSeven analogoues of tetradentate acyclic diaminodithioether (DADTE)ligands were synthesized and characterized. R₂SC(R₁)₂)CHnN(CH₂)mNCHn((R₁)₂C)SR₂ 222-gdm (L3): m = 1, n = 1, R₁ = -CH₃ and R₂ = -H; 222-gdm-pmBz (L4): m = 1, n = 1, R₁ =-CH₃, R₂ =-CH₂C₆H₅OCH₃; 232-gdm-pmBz (L7): m = 2, n = 1, R₁ = -CH₃, R₂ =-CH₂ C₆H₅OCH₃, 232-gdm-Met (L8): m = 2, n = 1, R₁ =-CH₃, R₂ =-CH₃, 232-Met (L10) m = 2, n = 1, R₁ = -H, R₂ =-CH₃, 323-Met (L12): m = 1, n = 2, R₁ = -H, R₂ =-CH₃ and 333-Met (L14): m = 2, n =2, R₁ = -H, R₂ = -CH₃). Rh(III) complexes of these DADTE ligands were prepared and the effect of the ligand backbone size on the configuration (cis and/or trans) has been studied. 105Rh radiolabeling studies were performed in order to investigate the optimum criteria for an ideal chelate such as high thermodynamic stability and kinetic inertness. Also, it is desirable that a single isomer with low lipophilicity properties is formed after complexation of the chelate. Complexation of 232-gdm-Met with 105Rh yielded a complex that fulfilled the minimum criteria. Coupling studies of 232-gdm-Met to Bombesin(7-14) analogues, Ahx-Met14-BBN(7-14) and Ahx-NLeu14-BBN(7-14), via an alternative approach have been accomplished. Finally, radiolabeling studies with 232-gdm-Met-Ahx-BBN(7-14) analogues were investigated to achieve an efficient 105Rh labeled BBN based target specific radiopharmaceutical. Structural changes on the DADTE ligand system have been effected to provide a Rh(III)-DADTE complex with optimum properties for an ideal chelate for targeted therapy applications. The alternative approach developed to attach the ligands to peptides yields 105Rh labeled Bombesin(7-14) without needing further functionalization on the ligand.eng
dc.identifier.merlinb59260269eng
dc.identifier.oclc159940449eng
dc.identifier.urihttps://hdl.handle.net/10355/4340
dc.identifier.urihttps://doi.org/10.32469/10355/4340eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subjectacyclic diaminodithioether.eng
dc.subjectacyclic diaminodithioethereng
dc.subject.lcshBombesineng
dc.subject.lcshRadiopharmaceuticals -- Designeng
dc.subject.lcshRhodium compoundseng
dc.titleSynthesis and evaluation of 105Rhodium(III) complexes derived from diaminodithioether (DADTE) ligandseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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