Specific bio-modeling and analysis techniques at cellular and systems level

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Specific bio-modeling and analysis techniques at cellular and systems level

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/4350

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dc.contributor.advisor Nair, Satish S., 1960- en
dc.contributor.author Jang, Tai Seung, 1971- en_US
dc.date.accessioned 2010-01-12T17:05:32Z
dc.date.available 2010-01-12T17:05:32Z
dc.date.issued 2006 en_US
dc.date.submitted 2006 Fall en
dc.identifier.other JangT-120806-D6054 en_US
dc.identifier.uri http://hdl.handle.net/10355/4350
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on August 2, 2007) en_US
dc.description Vita. en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (Ph. D.) University of Missouri-Columbia 2006. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Mechanical and aerospace engineering. en_US
dc.description.abstract Modeling approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on prefrontal cortical cells are elucidated with two possible hypotheses, and a systematic methodology to study the excitability of cells under inhibitory post synaptic currents (IPSCs) is developed. PART II focuses on mathematical models at the systems level. Specifically, thermal physiology models of the entire human body are developed using statistical and black box (artificial neural network, ANN) techniques.The MU 2-D Man, a human thermal model has been developed for designing an automatic thermal comfort control strategy for NASA astronaut space suits and for the US Air Force warfighters in chemo-bio suits. The model has been enhanced using more accurate modeling of digits incorporating arterio-venous anastomoses (AVA) mechanisms that the fingers and toes use for better control of heat transfer. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2006 Freely available dissertations (MU) en_US
dc.subject.lcsh Computational neuroscience en_US
dc.subject.lcsh Space biology en_US
dc.subject.lcsh Life support systems (Space environment) en_US
dc.subject.lcsh Extravehicular space suits en_US
dc.title Specific bio-modeling and analysis techniques at cellular and systems level en_US
dc.type Thesis en_US
thesis.degree.discipline Mechanical and aerospace engineering en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US
dc.identifier.merlin .b59270081 en_US
dc.identifier.oclc 162139859 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2006 Dissertations


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