How does the ratio of risk to benefit change with increasing doses of ibuprofen?
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Ibuprofen has greater analgesic efficacy with individual doses of 400 mg compared with 200 mg (SOR: A, systematic review of RCTs), but not at doses of more than 400 mg (SOR: B, single RCT). Higher cumulative daily doses of ibuprofen (>1,200-1,800 mg/d) are associated with an increased risk of cardiovascular (CV) events and more gastrointestinal (GI) complications (SOR: C, systematic review of case series).
Evidence Based Practice 17(7): 14