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dc.contributor.advisorChen, Shi-Jie, 1965-eng
dc.contributor.authorKopeikin, Zola, 1960-eng
dc.date.issued2006eng
dc.date.submitted2006 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file viewed on (February 27, 2007).eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionVita.eng
dc.descriptionThesis (Ph.D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physics.eng
dc.description.abstractIn this thesis, we develop statistical mechanical models for the folding of simple RNA tertiary structures. The focus is on the calculation of the tertiary structure conformational entropy. The key idea of the method is to account for the excluded volume correlations between different structural subunits by focusing on the interfacial regions. Tests against exhaustive computer lattice enumerations for chain conformations on a two-dimensional square lattice show that the model is accurate and reliable. The theory enables predictions for the free energy landscapes and conformational transitions for simple RNA tertiary folds and pseudoknots. Further applications to the force induced unfolding of RNA H-pseudoknots allow us to obtain the sequence-specific native structures, folding stabilities, pathways and folding cooperativities from the forcedependent free energy landscapes and the force-extension curves. Though the model is based on a two-dimensional lattice chain representation, the general principles developed in the model are directly applicable to the conformations at the atomic level.eng
dc.identifier.merlinb57901302eng
dc.identifier.oclc85379719eng
dc.identifier.urihttps://hdl.handle.net/10355/4360
dc.identifier.urihttps://doi.org/10.32469/10355/4360eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshRNA -- Analysiseng
dc.subject.lcshThermodynamicseng
dc.titleStatistical thermodynamics for RNA structures with simple tertiary contacts and pseudoknotseng
dc.typeThesiseng
thesis.degree.disciplinePhysics (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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