At what daily dose of ibuprofen does pain relief plateau?
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At what daily dose of ibuprofen does pain relief plateau? Evidence-Based Answer: Single-dose response of ibuprofen provides better analgesia at 200 and 400 mg when compared with placebo postoperatively. Daily doses of 1,200 and 2,400 mg ibuprofen provided significant pain relief compared with placebo (SOR: A, systematic review of RCTs). No statistical difference was noted in chronic pain relief for noninflammatory conditions at a daily dose of 1,200 mg/d compared with 2,400 mg/d (SOR: B, individual RCT).
Evidence Based Practice 17(9): E2-E3