What are the best medications for osteoarthritis?
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What are the best medications for osteoarthritis? Evidence-Based Answer: Acetaminophen is effective in reducing pain in patients with osteoarthritis (OA) compared with placebo, but NSAIDs appear to be better than acetaminophen for improving hip and knee pain. A standard NSAID with a PPI is about equivalent to a COX-2 inhibitor in the rates of gastrointestinal (GI) adverse events among patients with OA (SOR: A, meta-analyses). Tramadol with acetaminophen appears to be an effective add-on therapy for patients with OA taking COX-2 inhibitors or NSAIDs (SOR: B, individual RCTs).
Evidence Based Practice 17(9): E3-E4