Do antibiotics interfere with the efficacy of oral contraceptives?

Abstract

Do antibiotics interfere with the efficacy of oral contraceptives? Evidence-Based Answer: In patients taking oral contraceptive pills (OCPs), concomitant use of most antibiotics has not been associated with contraceptive failure (SOR: B, casecrossover study). Rifampin, however, may be associated with contraceptive failure (SOR: C, case report and opinion guideline).